Cook the penne pasta according to package instructions in a large pot of salted boiling water until al dente. Drain and set aside.
In a large skillet, heat the olive oil over medium heat. Add the chicken pieces and season with salt, pepper, Italian seasoning, and red pepper flakes. Cook until the chicken is browned and cooked through, about 5-7 minutes.
Add the minced garlic to the skillet and sauté for an additional 1-2 minutes until fragrant.
Pour in the heavy cream and bring to a gentle simmer. Stir in the grated Parmesan cheese until melted and the sauce is creamy.
Add the cooked penne pasta to the skillet and toss to coat the pasta evenly with the sauce. Cook for another 2-3 minutes to heat through.
Remove from heat and garnish with fresh parsley before serving.