Irresistible Pizza Casserole with Biscuits and Cheese Delight

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Pizza Casserole with Biscuits and Cheese

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The aroma of baking biscuits mingling with savory spices can transport you straight to a cozy kitchen gathering. Enter the Bubble Up Pizza Casserole, my go-to dish for those hectic weeknights when cooking feels like a mini crisis! This recipe is not only quick and easy to prepare, but it’s also a satisfying meal that pleases even the fussiest of eaters. With just six ingredients, you’ll whip up a hearty casserole that combines soft biscuit pieces with rich ground beef and zesty pizza sauce, creating a perfect comfort dish that the whole family will adore. Plus, it’s incredibly versatile—feel free to customize it with your favorite proteins or veggies for a little twist! Curious how to make this delightful dinner? Let’s dive in!

Why is this so irresistible?

Simplicity: With just six ingredients, this Bubble Up Pizza Casserole is a breeze to whip up, making it ideal for those busy weeknights or when you’re short on time.

Customizable: Whether you prefer chicken, turkey, or a vegetarian twist, this recipe allows you to easily swap out proteins or add your favorite veggies like spinach or mushrooms.


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Kid-Friendly: Its cheesy, familiar flavor profile wins over even the pickiest eaters, making it a go-to family favorite that you can enjoy together.

Perfect for Leftovers: This casserole tastes even better the next day! Simply store leftovers in an airtight container or freeze for later, and when you’re ready, just reheat for a delicious, quick meal.

Comforting Texture: The fluffy biscuit base combined with gooey cheese and hearty toppings creates a dish that’s both satisfying and nostalgic, reminiscent of the beloved pizza we all enjoy.

Enjoy this delicious bubble pizza casserole with a side salad or garlic bread for a complete meal! If you’re looking for more comforting recipes, check out my easy Egg Hashbrown Casserole or the flavorful Cream Cheese Chicken.

Pizza Casserole with Biscuits Ingredients

• Here’s everything you need for a delicious Pizza Casserole with Biscuits and Cheese!

For the Casserole

  • Lean Ground Beef – Provides protein and substance; substitute with turkey or chicken for a lighter meal.
  • Bell Peppers – Adds color and nutrition; can be omitted if you prefer a simpler casserole.
  • Pizza Sauce – Grants that classic pizza flavor; consider using a no-sugar-added sauce to keep it healthier.
  • Pillsbury Grands Biscuits – Forms the fluffy, comforting base; gluten-free alternatives are available for dietary needs.
  • Shredded Mozzarella Cheese – Introduces melty texture; can be replaced with cheddar or non-dairy cheese if preferred.
  • Sliced Turkey Pepperoni – Adds bold flavor and extra protein; feel free to use regular pepperoni or skip it for a vegetarian version.

Enjoy gathering these ingredients to create a comforting evening meal that your whole family will rave about!

Step‑by‑Step Instructions for Pizza Casserole with Biscuits and Cheese

Step 1: Preheat the Oven
Begin by preheating your oven to 375°F (190°C). While that’s warming up, grab a 9×13 inch baking dish and lightly grease it with cooking spray or a bit of olive oil. This will ensure that your delicious Pizza Casserole with Biscuits and Cheese doesn’t stick to the pan as it bakes.

Step 2: Cook the Ground Beef
Heat a large skillet over medium heat and add lean ground beef. Cook for 3-4 minutes, breaking it up with a spatula until it’s no longer pink. For enhanced flavor, season with salt and pepper. You’ll know it’s ready when the beef is nicely browned and has a crumbly texture, creating a savory base for your casserole.

Step 3: Sauté the Vegetables
Next, add diced bell peppers to your skillet with the cooked beef. Sauté for about 3-5 minutes, stirring occasionally, until the peppers are soft and vibrant. This adds color and nutrition to your Pizza Casserole with Biscuits and Cheese. Once they’re tender, drain any excess liquid to keep your casserole from becoming soggy.

Step 4: Mix in the Pizza Sauce
Pour in your choice of pizza sauce into the skillet with the beef and bell peppers. Stir everything together until well combined, letting the mixture simmer for a minute or two to meld the flavors. You’ll want the sauce to be evenly distributed, ensuring that every bite of your casserole is bursting with that classic pizza flavor.

Step 5: Prepare the Biscuits
While the meat mixture simmers, take your Pillsbury Grands Biscuits and cut each biscuit into six pieces. Scatter these biscuit pieces evenly in the greased baking dish, forming a fluffy base for the Pizza Casserole with Biscuits and Cheese. This layer will become delectably soft and absorb the pizza sauce flavors as it bakes.

Step 6: Combine the Mixtures
Now, gently fold the beef and veggie mixture into the bowl of biscuit pieces. Stir carefully to coat the biscuit pieces without breaking them apart. Spread the mixture evenly in the baking dish, ensuring that each piece is enveloped in that rich, savory filling, setting the stage for wonderful textures in your casserole.

Step 7: Add Cheese and Pepperoni
Next, sprinkle shredded mozzarella cheese generously over the top of your casserole mixture, allowing it to melt delightfully during baking. Then, add sliced turkey pepperoni evenly across the cheese layer for an extra flavor boost. This will create a beautiful, cheesy crust that’s visually appealing and utterly delicious.

Step 8: Bake the Casserole
Place your assembled casserole dish in the preheated oven and bake uncovered for 25-30 minutes. You’ll know it’s done when the casserole is bubbly and the biscuit tops turn golden brown. The inviting aroma wafting through your kitchen will have everyone eager to dig in!

Step 9: Cool and Serve
Once baked to perfection, remove the casserole from the oven and let it cool for 5-10 minutes. This resting time helps the flavors settle and makes it easier to slice. As you cut into this flavorful Pizza Casserole with Biscuits and Cheese, you’ll reveal those gooey layers ready to be enjoyed.

Pizza Casserole with Biscuits Variations

Feel free to get creative and tailor the Bubble Up Pizza Casserole to your family’s taste buds with these delightful twists!

  • Vegetarian Delight: Substitute the ground beef and turkey pepperoni with sautéed mushrooms, zucchini, or spinach for a hearty veggie version everyone will love.

  • Spicy Kick: Add diced jalapeños or crushed red pepper flakes to the beef mixture for an extra spicy burst of flavor that’ll warm you up from the inside out.

  • Cheesy Swap: Instead of mozzarella, try pepper jack cheese or gouda for a fun twist that introduces new flavors and melts beautifully.

  • Gluten-Free: Use gluten-free biscuits to ensure those with dietary restrictions can still enjoy this hearty casserole without worry.

  • Protein Boost: Incorporate cooked and crumbled sausage or diced grilled chicken for an additional protein punch that complements the dish beautifully.

  • Flavorful Sauce: Swap in pesto or alfredo sauce for an exciting take on the classic pizza flavor profile, creating a unique twist on this comforting dish.

  • Mini Casserole: Make individual servings by using muffin tins! Layer biscuit pieces and toppings for a fun twist that’s perfect for portion control and kids.

  • Herb Infusion: Add fresh herbs like basil, oregano, or parsley to the mixture for a burst of freshness that elevates the entire casserole experience.

Each of these variations opens up new possibilities for your Bubble Up Pizza Casserole. For a touch of variety, serve it alongside a fresh side salad or some toasted garlic bread. If you’re looking for more comforting dishes, you might enjoy my easy Egg Hashbrown Casserole or the delicious Cream Cheese Chicken. Happy cooking!

What to Serve with Bubble Up Pizza Casserole

Transform your weeknight dinner with delightful sides that balance and enhance the rich flavors of this comforting casserole.

  • Garlic Bread: A warm loaf of garlic bread complements the casserole’s cheesy goodness, perfect for sopping up every last bite.
  • Side Salad: A fresh green salad with a zesty vinaigrette adds crispness and a refreshing touch to the hearty casserole.
  • Roasted Vegetables: Seasonal roasted veggies offer a colorful, nutritious contrast to the rich casserole while adding robust flavors.
  • Coleslaw: Creamy coleslaw brings a crunchy texture that contrasts beautifully with the soft, gooey casserole, making each forkful exciting.
  • Zucchini Noodles: Light and lean, zucchini noodles serve as a low-carb, vibrant alternative that takes the meal to a healthier level while still being delicious.
  • Fruit Salad: A sweet fruit salad for dessert rounds off the meal nicely, providing a refreshing and light finish after the savory casserole.
  • Sparkling Water: Enjoy with sparkling water or a light soda to cleanse the palate between rich bites, adding a fun touch to dinner.
  • Chocolate Brownies: For dessert, serve decadent chocolate brownies that bring a sweet, indulgent contrast to the savory main dish.
  • Pasta Salad: A cold pasta salad with veggies and dressing introduces a fun, textured element that pairs well with the casserole.

How to Store and Freeze Pizza Casserole

Airtight Storage: Store leftovers in an airtight container in the fridge for up to 3-4 days. This keeps your delicious Pizza Casserole with Biscuits and Cheese fresh and ready for quick meals!

Freezing Instructions: For longer storage, wrap individual portions tightly in plastic wrap and then foil. Freeze for up to 3 months—perfect for those last-minute dinner cravings.

Reheating Tips: To reheat frozen portions, place them in a preheated oven at 350°F for about 25-30 minutes or until warmed through. This method preserves the cozy, comforting texture of the casserole.

Thawing Guidance: If you prefer to thaw, transfer the casserole to the fridge overnight before reheating. This makes it easier to reheat evenly without compromising taste!

Make Ahead Options

These Bubble Up Pizza Casserole are perfect for meal prep enthusiasts! You can assemble the casserole up to 24 hours in advance by preparing all the layers and then refrigerating it before baking. Simply cook the ground beef and sauté the vegetables, then mix everything together with the biscuit pieces in your baking dish. Cover tightly and refrigerate until you’re ready to bake. When you’re set to serve, just pop it in the oven and bake as directed for a quick, hassle-free meal that tastes just as delicious as fresh. This allows you to enjoy flavorful homemade comfort food with minimal effort, making dinner times smoother on busy nights!

Expert Tips for Pizza Casserole with Biscuits

  • Drain Properly: Make sure to drain excess liquid from the beef and vegetable mixture to prevent a soggy Pizza Casserole with Biscuits and Cheese.

  • Broil for Crispiness: For a golden, crispy topping, briefly broil the casserole at the end of baking. Just keep an eye on it to avoid burning!

  • Check Biscuit Doneness: Use a knife to check if the biscuit pieces are cooked through; it should come out clean. This ensures every bite is fluffy and delicious.

  • Make Ahead: You can prepare the casserole up to the baking step and store it in the fridge for up to 24 hours, making dinner time easier!

  • Customize Flavor: Feel free to substitute the cheese or add extra spices to the sauce for a personalized flavor. Enjoy experimenting to match your family’s tastes!

Pizza Casserole with Biscuits and Cheese Recipe FAQs

How do I choose the best ground beef for this recipe?
Absolutely! Look for lean ground beef, ideally 90% lean or higher to keep your casserole hearty but not too greasy. If you prefer a lighter option, ground turkey or chicken works beautifully here too. These alternatives are flavorful and still provide that satisfying protein kick!

What’s the best way to store leftover Pizza Casserole with Biscuits and Cheese?
Very! Store your leftovers in an airtight container in the refrigerator. They should stay fresh for about 3-4 days. This makes it super convenient for quick lunches or dinners throughout the week. Just reheat in the microwave or oven, and you’ll have a delightful meal waiting for you!

Can I freeze Pizza Casserole with Biscuits and Cheese?
Definitely! To freeze, first wrap individual portions tightly in plastic wrap, then cover them with foil. This layering helps prevent freezer burn. The casserole can be stored in the freezer for up to 3 months. When you’re ready to eat, simply reheat from frozen in a preheated oven at 350°F for about 25-30 minutes or until heated through. It’s a lifesaver for busy nights!

What if I want to make this recipe vegetarian?
You can absolutely customize it! Just omit the ground beef and turkey pepperoni, and replace them with your favorite plant-based proteins like tofu or tempeh. You can also amp up the vegetable content by adding ingredients like mushrooms, zucchini, or spinach for an extra nutritious boost!

How can I prevent the casserole from getting soggy?
The key to a perfect texture is to drain any excess liquid from the beef and vegetable mixture before combining it with the biscuits. Also, make sure to avoid overcooking the vegetables, as they can release moisture. If you want a crispier top, you can briefly broil the casserole at the end, just keep an eye on it to avoid burning!

What should I do if the biscuits aren’t cooked through after baking?
If you find that the biscuits aren’t fully cooked, you can cover the casserole with aluminum foil to prevent over-browning and return it to the oven for an additional 5-10 minutes. Check again with a knife; it should come out clean when the biscuits are done. Enjoy that comforting, fluffy goodness!

Pizza Casserole with Biscuits and Cheese

Irresistible Pizza Casserole with Biscuits and Cheese Delight

This Pizza Casserole with Biscuits and Cheese is quick, customizable, and a family-friendly meal that combines delicious flavors for a cozy dinner.
Prep Time 10 minutes
Cook Time 30 minutes
Cooling Time 10 minutes
Total Time 50 minutes
Servings: 6 servings
Course: Dinner
Cuisine: American
Calories: 450

Ingredients
  

For the Casserole
  • 1 pound Lean Ground Beef Can substitute with turkey or chicken.
  • 1 cup Bell Peppers Diced; can be omitted.
  • 1 cup Pizza Sauce Consider low-sugar option.
  • 1 can Pillsbury Grands Biscuits Gluten-free options available.
  • 2 cups Shredded Mozzarella Cheese Can replace with cheddar or non-dairy cheese.
  • 1 cup Sliced Turkey Pepperoni Regular pepperoni can be used.

Equipment

  • Oven
  • Skillet
  • Baking Dish

Method
 

Preparation Steps
  1. Preheat your oven to 375°F (190°C) and grease a 9x13 inch baking dish.
  2. In a skillet over medium heat, cook lean ground beef for 3-4 minutes until browned. Season with salt and pepper.
  3. Add diced bell peppers to the beef and sauté for 3-5 minutes until tender. Drain excess liquid.
  4. Pour pizza sauce into the skillet and mix until combined. Let simmer for 1-2 minutes.
  5. Cut each biscuit into six pieces and scatter them in the greased baking dish.
  6. Gently fold the beef and veggie mixture into the biscuit pieces, mixing carefully.
  7. Sprinkle shredded mozzarella cheese on top, then add sliced turkey pepperoni.
  8. Bake uncovered for 25-30 minutes until bubbly and golden brown.
  9. Remove from oven and allow to cool for 5-10 minutes before serving.

Nutrition

Serving: 1servingCalories: 450kcalCarbohydrates: 30gProtein: 25gFat: 25gSaturated Fat: 10gPolyunsaturated Fat: 1gMonounsaturated Fat: 12gCholesterol: 70mgSodium: 800mgPotassium: 400mgFiber: 2gSugar: 3gVitamin A: 15IUVitamin C: 50mgCalcium: 20mgIron: 15mg

Notes

This casserole can be made ahead of time and stored in the fridge for easier dinner prep. Customize flavors as desired.

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